Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Ppack TFA | 157379-44-7 | 99.8% | 5 MG
PPACK TFA is a potent, selective, and irreversible thrombin inhibitor supplied as the trifluoroacetate (TFA) salt. It is used as an anticoagulant alternative for blood gas and whole-blood electrolyte analyses and inhibits plasminogen activator (rt-PA) binding to plasma protease inhibitors.
- Irreversible thrombin inhibitor for anticoagulant applications.
- Supplied as the trifluoroacetate salt for stability and handling.
- High analytical purity (99.8%).
- Suitable for blood gas and whole-blood electrolyte analyses.
- Available in a 5 mg research-size vial.
- CAS number: 157379-44-7.
Medchemexpress LLC LY117018 TFA 5mg | 2390041-98-0 | 573.58 | C29H26F3NO6S | 5 MG
LY117018 TFA is the trifluoroacetic acid salt of LY117018, a raloxifene analog and selective estrogen receptor modulator reported to exert antiproliferative effects on breast cancer cell lines. It is provided as a research reagent for in vitro and in vivo studies of estrogen receptor signaling and related pathways.
- Selective estrogen receptor modulator with reported antiproliferative activity.
- Soluble in DMSO up to 100 mg/mL; sonication may be required.
- In vivo formulations reported with solubility ≈5 mg/mL using common co-solvent systems.
- Recommended storage: solid sealed and kept away from moisture; in solution store at -80°C (up to 6 months) or -20°C (up to 1 month).
- Molecular formula C29H26F3NO6S; molecular weight 573.58.
![Medchemexpress LLC L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.87% | 1323.35 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000384391-logo.png-250.jpg){kind=logo}
Medchemexpress LLC L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.87% | 1323.35 | 25 MG
L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.87% | 1323.35 | 25 MG
Selleck Chemical LLC Z-LEHD-FMK TFA
Z-LEHD-FMK TFA (Caspase-9 Inhibitor) is a cell-permeable competitive and irreversible inhibitor of enzyme caspase-9 which helps in cell survival
Medchemexpress LLC Z-VRPR-FMK TFA (VRPR) | 95.0% | 790.81 | 200 UG
Z-VRPR-FMK TFA (VRPR) is a tetrapeptide and a selective, irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. It can protect against influenza A virus (IAV) infection.
- Selective and irreversible MALT1 inhibitor
- Protects against influenza A virus (IAV) infection
Medchemexpress LLC Calcitonin, eel TFA | 99.9% | 3528.89 | 5 MG
Calcitonin, eel TFA is a thyroid hormone peptide that plays a role in regulating calcium homeostasis. It is frequently used in research concerning postmenopausal osteoporosis. In vitro studies show that Calcitonin, eel stimulates phosphoinositide hydrolysis and prolactin release in cultured anterior pituitary cells more effectively than salmon calcitonin. However, it does not inhibit prolactin release under conditions stimulated by thyrotropin releasing hormone (TRH).
- Contributes to the regulation of calcium homeostasis.
- Widely used in postmenopausal osteoporosis research.
- Effectively induces a concentration-dependent stimulation of phosphoinositide hydrolysis in vitro.
- Stimulates prolactin release in cultured anterior pituitary cells in vitro.
- High purity of 99.91%.
Medchemexpress LLC Cyclo(Arg-Pro) TFA | 98.6% | 367.32 | 50 MG
Cyclo(Arg-Pro) TFA is identified as a chitinase inhibitor that impacts cell separation and morphological transitions in yeast by hindering chitinase activity. It specifically prevents cell separation in Saccharomyces cerevisiae, leading to the formation of grape-like cell clusters, without impeding cell growth. Furthermore, it blocks the morphological transition of Candida albicans from its yeast form to its hyphal form, also without inhibiting cell growth.
- Chitinase inhibitor
- Disrupts cell separation in yeast by inhibiting chitinase activity
- Prevents cell separation of Saccharomyces cerevisiae without inhibiting cell growth
- Blocks morphological transition of Candida albicans from yeast to hyphal form without inhibiting cell growth
- For research use only